Job Title: Post-Doctoral Fellow
Location: Yale School of Medicine, New Haven, CT
Postdoctoral position immediately available to investigate the genetic and molecular mechanisms that underlie congenital heart disease. The Gruber lab utilizes a multi-disciplinary approach to investigate the molecular and genetic basis of human congenital heart disease. Through deep sequencing (WES and WGS) of both large cohorts and informative families, we have a identified several novel genetic associations that require mechanistic investigation. Recent work (Circulation, JCI Insight, Dev Cell, Stem Cells) has uncovered a series of progenitor cell populations whose single cell transcriptional signal is enriched with damaging mutations identified in human cohorts. Our lab employs mouse modeling, tissue culture, human ES and iPSC targeting, biochemical assays, and a variety of informatic approaches to understand the mechanisms that guide tissue movements in the developing heart. The applicant should be highly motivated with a PhD or MD/PhD and be prepared to perform self-directed research in a close-knit laboratory environment at Yale University. Prior experience in molecular biological techniques, mouse modeling, and a knowledge of Python and/or R is preferred.
PhD or MD/PhD
Experience in mouse modeling and colony management is preferred.
Equal Employment Opportunity
Yale University is an Affirmative Action/Equal Opportunity employer. Upon request, reasonable accommodations in the application process will be provided to individuals with disabilities. Yale University is committed to diversity in its workforce. Women and minorities are encouraged to apply.
How to Apply
In addition to applying online, the applicant should send a CV and the names of two faculty-level references to:
Peter J. Gruber, MD, PhD
Yale University School of Medicine